Biological Mass Spectrometry

Dividing cells undergo dramatic structural changes including nuclear envelope breakdown, chromosome condensation and formation of the mitotic spindle apparatus. The major task of this cellular reorganization is to faithfully disseminate genetic information to daughter cells. Macromolecular protein assemblies provide a structural framework and serve as central integration sites for regulatory mechanisms that ensure the correct order of these events. We combine mass spectrometry, chemical cross-linking, biochemistry and cell biology to investigate the architecture of such cellular protein structures and how they are assembled in a cell cycle regulated manner.


We have one open postdoc position and are always looking for highly motivated Master and PhD students. Please contact me by email:


Selected Publications

Grimm et al. (2015) xVis: a web server for the schematic visualization and interpretation of crosslink-derived spatial restraints. Nucleic Acids Res

Plaschka et al. (2015) Architecture of the RNA polymerase II–Mediator core initiation complex. Nature

Tosi et al. (2013) Structure and Subunit Topology of the INO80 Chromatin Remodeler and Its Nucleosome Complex. Cell

Herzog et al. (2012) Structural probing of a protein phosphatase 2A network by chemical cross-linking and mass spectrometry. Science

Herzog et al. (2009) Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex. Science